Embryonic signals perpetuate polar-like trophoblast stem cells and pattern the blastocyst axis.

Frias-Aldeguer J, Kip M, Vivié J, Li L, Alemany A, Korving J, Darmis F, van Oudenaarden A, Van Blitterswijk CA, Geijsen N, Rivron NC [corresponding author]. BioRxiv 510362; doi:

Chemically-defined induction of a primitive endoderm and epiblast-like niche supports post-implantation progression from blastoids.

Vrij EJ, Scholte op Reimer YS, Frias Aldeguer J, Misteli Guerreiro I, Kind J, Koo BK, van Blitterswijk CA, Rivron NC [corresponding author]. BioRxiv 510396; doi:

Debate ethics of embryo models from stem cells.

Rivron N [corresponding author], Pera M [corresponding author], Rossant J, Martinez Arias A, Zernicka-Goetz M, Fu J, van den Brink S, Bredenoord A, Dondorp W, de Wert G, Hyun I, Munsie M, Isasi R. Nature. 2018 Dec;564(7735):183-185. doi: 10.1038/d41586-018-07663-9.

Blastocyst-like structures generated solely from stem cells.

Nicolas C Rivron [corresponding author], Javier Frias-Aldeguer, Erik J Vrij, Jean-Charles Boisset, Jeroen Korving, Judith Vivié, Roman K Truckenmüller, Alexander van Oudenaarden, Clemens A van Blitterswijk †, Niels Geijsen † [† equal contribution]. Nature. 2018. 557, pages106–111 (2018). doi:10.1038/s41586-018-0051-0.

Formation of blastoids from mouse embryonic and trophoblast stem cells

Nicolas C Rivron. Protocol exchange. 2018. doi:10.1038/protex.2018.051.

Troy+ brain stem cells cycle through quiescence and regulate their number bysensing niche occupancy.

Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E610 E619. doi:10.1073/pnas.1715911114. Epub 2018 Jan 8. PubMed PMID: 29311336.

Creating to understand - developmental biology meets engineering in Paris.

Kicheva A, Rivron NC. Development. 2017 Mar 1;144(5):733-736. doi:10.1242/dev.144915. PubMed PMID: 28246208.

Directed assembly and development of material-free tissues with complex architectures.

Vrij E, Rouwkema J, LaPointe V, van Blitterswijk C, Truckenmüller R, Rivron N. Adv Mater. 2016 Jun;28(21):4032-9. doi: 10.1002/adma.201505723. Epub 2016 Mar 22. PubMed PMID: 27000493.

3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates.

Vrij EJ, Espinoza S, Heilig M, Kolew A, Schneider M, van Blitterswijk CA,Truckenmüller RK, Rivron NC. Lab Chip. 2016 Feb21;16(4):734-42. doi: 10.1039/c5lc01499a. Epub 2016 Jan 18. PubMed PMID: 26775648.

Engineered micro-objects as scaffolding elements in cellular building blocks for bottom-up tissue engineering approaches.

Leferink A, Schipper D, Arts E, Vrij E, Rivron N, Karperien M, Mittmann K, vanBlitterswijk C, Moroni L, Truckenmüller R. Adv Mater. 2014 Apr 23;26(16):2592-9. doi:10.1002/adma.201304539. Epub 2014 Jan 7. PubMed PMID: 24395427.

Spheroid culture as a tool for creating 3D complex tissues.

Fennema E, Rivron N, Rouwkema J, van Blitterswijk C, de Boer J. Trends Biotechnol. 2013 Feb;31(2):108-15. doi: 10.1016/j.tibtech.2012.12.003. Epub 2013 Jan 18. Review. PubMed PMID: 23336996.

Tissue deformation spatially modulates VEGF signaling and angiogenesis.

Rivron NC, Vrij EJ, Rouwkema J, Le Gac S, van den Berg A, Truckenmüller RK,van Blitterswijk CA. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6886-91. doi:10.1073/pnas.1201626109. Epub 2012 Apr 17. PubMed PMID: 22511716; PubMed Central PMCID: PMC3344996.

Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation.

Rivron NC, Raiss CC, Liu J, Nandakumar A, Sticht C, Gretz N, Truckenmüller R, Rouwkema J, van Blitterswijk CA. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4413-8. doi: 10.1073/pnas.1117627109. Epub 2012 Mar 2. PubMed PMID: 22388744; PubMed Central PMCID: PMC3311342.

Fabrication of cell container arrays with overlaid surface topographies.

Truckenmüller R, Giselbrecht S, Escalante-Marun M, Groenendijk M, Papenburg B,Rivron N, Unadkat H, Saile V, Subramaniam V, van den Berg A, van Blitterswijk C, Wessling M, de Boer J, Stamatialis D. Biomed Microdevices. 2012 Feb;14(1):95-107. doi:10.1007/s10544-011-9588-5. PubMed PMID: 22048776; PubMed Central PMCID:PMC3288368.

Thermoforming of film-based biomedical microdevices.

Truckenmüller R, Giselbrecht S, Rivron N, Gottwald E, Saile V, van den Berg A, Wessling M, van Blitterswijk C. Adv Mater. 2011 Mar 18;23(11):1311-29. doi: 10.1002/adma.201003538. Epub 2011 Jan 31. Review. PubMed PMID: 21400590.

Tissue assembly and organization: developmental mechanisms in microfabricated tissues.

Rivron NC, Rouwkema J, Truckenmüller R, Karperien M, De Boer J, VanBlitterswijk CA. Biomaterials. 2009 Oct;30(28):4851-8. doi:10.1016/j.biomaterials.2009.06.037. Epub 2009 Jul 9. PubMed PMID: 19592088.

Vascularization in tissue engineering.

Rouwkema J, Rivron NC, van Blitterswijk CA. Trends Biotechnol. 2008 Aug;26(8):434-41. doi:10.1016/j.tibtech.2008.04.009. Epub 2008 Jun 26. Review. PubMed PMID: 18585808.

©2017 by Nicolas Rivron Lab.