Stem cell-based genesis
Stem cells are the seeds for organs and organisms, with the capacity to multiply, to generate specialized cells, and to organize into sophistically patterned and functional structures. Stem cells achieve such complex behaviour via genetically encoded molecular networks and communication mechanisms allowing them to take partly deterministic, stochastic and coordinated decisions.
We seek for the general principles underlying the communication and organization of stem cells that lead to the formation of organs and organisms.
To reveal these principles, we build organs and organisms in-a-dish from stem cells by harnessing their intrinsic potential to self-organize. This approach allows to systematically modulate and analyse behaviour, while generating large numbers of organs or organisms for drug and genetic screens, biochemistry and genomic analysis.
Our group is interdisciplinary by nature. It gathers scientists and engineers whose research is grounded in fundamental stem cell biology, technological and computational approaches (e.g. microsystems, single cell sequencing, three-dimensional high content screens). We apply this interdisciplinary approach to develop novel stem cell-based models, investigate the design principles governing development and diseases, and collaborate to propose solutions to global health problems.